The England midfielder suffered the injury during the Blues’ 3-0 friendly win over New England Revolution in Boston on Wednesday.
Loftus-Cheek has hit a rich vein of form over recent weeks but will miss the Europa League final against Arsenal in Baku at the end of this month as he begins a long road to recovery.
England manager Gareth Southgate had already left 23-year-old out of his squad for the Nations League Finals earlier on Thursday.
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